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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345007
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP2E1
Name: cytochrome P450 family 2 subfamily E member 1
Acc ID: CHEBI:35255
Term: chloroform
Definition: A one-carbon compound that is methane in which three of the hydrogens are replaced by chlorines.
Chemical ID: MESH:D002725
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP2E1increases metabolic processingEXP 6480464CTDCYP2E1 protein results in increased metabolism of ChloroformPMID:18350910
CYP2E1increases oxidationEXP 6480464CTDCYP2E1 protein results in increased oxidation of ChloroformPMID:1664256
CYP2E1increases response to substanceEXP 6480464CTDCYP2E1 gene SNP results in increased susceptibility to ChloroformPMID:15289170
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