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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620944
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp7
Name: caspase 7
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp7increases activityEXP 6480464CTDParaquat results in increased activity of CASP7 proteinPMID:17324951 PMID:22678742
Casp7multiple interactionsEXP 6480464CTDNFE2L2 mutant form inhibits the reaction [Paraquat results in increased activity of CASP7 protein]PMID:22678742
Casp7increases activityISOCASP7 (Homo sapiens)6480464CTDParaquat results in increased activity of CASP7 proteinPMID:24866057
Casp7increases expressionISOCASP7 (Homo sapiens)6480464CTDParaquat results in increased expression of CASP7 mRNAPMID:18836921
Casp7multiple interactionsISOCASP7 (Homo sapiens)6480464CTDCAT protein inhibits the reaction [Paraquat results in increased activity of CASP7 protein]PMID:24866057
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