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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1347817
Species: Homo sapiens
RGD Object: Gene
Symbol: DNAJC3
Name: DnaJ heat shock protein family (Hsp40) member C3
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
DNAJC3increases expressionEXP 6480464CTDParaquat results in increased expression of DNAJC3 mRNAPMID:31966674
DNAJC3multiple interactionsEXP 6480464CTDDNAJC3 protein affects the reaction [Paraquat results in increased expression of BAX protein]; DNAJC3 protein inhibits the reaction [Paraquat results in decreased expression of AKT1 mRNA]; DNAJC3 protein inhibits the reaction [Paraquat results in decreased phosphorylation of AKT1 protein]; DNAJC3 protein inhibits the reaction [Paraquat results in increased expression of BAX mRNA]; DNAJC3 protein inhibits the reaction [Paraquat results in increased expression of BAX protein]; DNAJC3 protein inhibits the reaction [Paraquat results in increased expression of DDIT3 mRNA]; DNAJC3 protein inhibits the reaction [Paraquat results in increased expression of DDIT3 protein]; DNAJC3 protein promotes the reaction [Paraquat results in increased expression of BCL2 mRNA]PMID:31966674
DNAJC3decreases expressionISODnajc3 (Mus musculus)6480464CTDParaquat results in decreased expression of DNAJC3 mRNAPMID:16797015
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