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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305471
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Atf6
Name: activating transcription factor 6
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Atf6increases expressionEXP 6480464CTDParaquat results in increased expression of ATF6 proteinPMID:22245251
Atf6multiple interactionsEXP 6480464CTDMinocycline inhibits the reaction [Paraquat results in increased expression of ATF6 protein]PMID:22245251
Atf6increases cleavageISOATF6 (Homo sapiens)6480464CTDParaquat results in increased cleavage of ATF6 proteinPMID:28986289
Atf6increases expressionISOATF6 (Homo sapiens)6480464CTDParaquat results in increased expression of ATF6 mRNA; Paraquat results in increased expression of ATF6 protein modified formPMID:28986289 PMID:34097952
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