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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736485
Species: Mus musculus
RGD Object: Gene
Symbol: Sqstm1
Name: sequestosome 1
Acc ID: CHEBI:34887
Term: nickel dichloride
Definition: A compound of nickel and chloride in which the ratio of nickel (in the +2 oxidation state) to chloride is 1:2.
Chemical ID: MESH:C022838
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sqstm1decreases expressionEXP 6480464CTDnickel chloride results in decreased expression of SQSTM1 mRNA; nickel chloride results in decreased expression of SQSTM1 proteinPMID:36421005
Sqstm1multiple interactionsEXP 6480464CTD[nickel chloride results in increased abundance of Nickel] which affects the expression of and affects the localization of SQSTM1 protein; Melatonin inhibits the reaction [nickel chloride results in decreased expression of SQSTM1 mRNA]; Melatonin inhibits the reaction [nickel chloride results in decreased expression of SQSTM1 protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in decreased expression of SQSTM1 mRNA]]; TXNRD3 gene mutant form promotes the reaction [nickel chloride results in decreased expression of SQSTM1 mRNA]; TXNRD3 gene mutant form promotes the reaction [nickel chloride results in decreased expression of SQSTM1 protein]PMID:36421005 PMID:36794572
Sqstm1affects expressionISOSqstm1 (Rattus norvegicus)6480464CTDnickel chloride affects the expression of SQSTM1 mRNAPMID:22546817
Sqstm1increases expressionISOSqstm1 (Rattus norvegicus)6480464CTDnickel chloride results in increased expression of SQSTM1 mRNAPMID:22110744
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