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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621676
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Acta2
Name: actin alpha 2, smooth muscle
Acc ID: CHEBI:34887
Term: nickel dichloride
Definition: A compound of nickel and chloride in which the ratio of nickel (in the +2 oxidation state) to chloride is 1:2.
Chemical ID: MESH:C022838
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acta2increases expressionISOACTA2 (Homo sapiens)6480464CTDnickel chloride results in increased expression of ACTA2 mRNA; nickel chloride results in increased expression of ACTA2 proteinPMID:30055191
Acta2increases expressionISOActa2 (Mus musculus)6480464CTDnickel chloride results in increased expression of ACTA2 proteinPMID:30055191
Acta2multiple interactionsISOACTA2 (Homo sapiens)6480464CTDsodium bisulfide inhibits the reaction [nickel chloride results in increased expression of ACTA2 mRNA]; sodium bisulfide inhibits the reaction [nickel chloride results in increased expression of ACTA2 protein]PMID:30055191
Acta2multiple interactionsISOActa2 (Mus musculus)6480464CTDCTH gene mutant form promotes the reaction [nickel chloride results in increased expression of ACTA2 protein]PMID:30055191
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