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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62109
Species: Mus musculus
RGD Object: Gene
Symbol: Col1a1
Name: collagen, type I, alpha 1
Acc ID: CHEBI:34873
Term: N-nitrosodiethylamine
Definition: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Chemical ID: MESH:D004052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Col1a1increases expressionISOCol1a1 (Rattus norvegicus)6480464CTDDiethylnitrosamine results in increased expression of COL1A1 mRNAPMID:19638242
Col1a1multiple interactionsISOCol1a1 (Rattus norvegicus)6480464CTD[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of COL1A1 mRNA; [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of COL1A1 mRNA; [Diethylnitrosamine co-treated with Phenobarbital] results in increased methylation of COL1A1 promoter; [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] affects the expression of COL1A1 mRNA; [Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of COL1A1 mRNAPMID:18164116 PMID:20045035 PMID:21295105 PMID:23830814 PMID:25374375 PMID:28943392
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