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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1346751
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP2B6
Name: cytochrome P450 family 2 subfamily B member 6
Acc ID: CHEBI:34873
Term: N-nitrosodiethylamine
Definition: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Chemical ID: MESH:D004052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP2B6multiple interactionsISOCyp2b10 (Mus musculus)6480464CTD[2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylnitrosamine] results in increased expression of CYP2B10 mRNA; [Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of CYP2B10 mRNA; [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of CYP2B10 mRNA; [Diethylnitrosamine co-treated with Piperonyl Butoxide] results in increased expression of CYP2B10 mRNA; [Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of CYP2B10 mRNA; NR1I3 protein affects the reaction [[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of CYP2B10 mRNA]PMID:15492232 PMID:17917374 PMID:19690152 PMID:20101389 PMID:23457121 PMID:33398415
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