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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3636
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Scn4a
Name: sodium voltage-gated channel alpha subunit 4
Acc ID: CHEBI:34393
Term: 4-chloro-3,5-dimethylphenol
Definition: A member of the class of phenols that is 3,5-xylenol which is substituted at position 4 by chlorine. It is bactericidal against most Gram-positive bacteria but less effective against Staphylococci and Gram-negative bacteria, and often inactive against Pseudomonas species. It is ineffective against bacterial spores.
Chemical ID: MESH:C007027
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Scn4aaffects activityISOSCN4A (Homo sapiens)6480464CTDchloroxylenol affects the activity of SCN4A protein polymorphismPMID:11282107
Scn4amultiple interactionsISOSCN4A (Homo sapiens)6480464CTDchloroxylenol binds to and results in decreased activity of SCN4A proteinPMID:14662728
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