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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1592345
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mt2A
Name: metallothionein 2A
Acc ID: CHEBI:3423
Term: carmustine
Definition: A member of the class of N-nitrosoureas that is 1,3-bis(2-chloroethyl)urea in which one of the nitrogens is substituted by a nitroso group.
Chemical ID: MESH:D002330
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mt2Aaffects response to substanceEXP 6480464CTDMT2 protein affects the susceptibility to CarmustinePMID:18528683
Mt2Amultiple interactionsEXP 6480464CTDMT2 protein inhibits the reaction [Carmustine results in decreased activity of GSR protein]; MT2 protein inhibits the reaction [Carmustine results in increased expression of TNF protein]PMID:18528683
Mt2Aaffects response to substanceISOMT2A (Homo sapiens)6480464CTDMT2A mRNA affects the susceptibility to CarmustinePMID:16365179
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