GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Esr1 | affects binding | EXP | | 6480464 | CTD | o,p'-DDT binds to ESR1 protein | PMID:11162928 PMID:19913605 | Esr1 | decreases expression | EXP | | 6480464 | CTD | o,p'-DDT results in decreased expression of ESR1 mRNA | PMID:28263910 | Esr1 | affects binding | ISO | Esr1 (Rattus norvegicus) | 6480464 | CTD | o,p'-DDT binds to ESR1 protein | PMID:11086226 | Esr1 | affects binding | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | o,p'-DDT binds to ESR1 protein | PMID:12676605 PMID:14579009 PMID:19913605 PMID:20074635 | Esr1 | decreases expression | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | o,p'-DDT results in decreased expression of ESR1 mRNA; o,p'-DDT results in decreased expression of ESR1 protein | PMID:11867264 PMID:18700809 PMID:20206645 | Esr1 | increases activity | ISO | Esr1 (Rattus norvegicus) | 6480464 | CTD | o,p'-DDT results in increased activity of ESR1 protein | PMID:28531659 PMID:9860891 | Esr1 | increases activity | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | o,p'-DDT results in increased activity of ESR1 protein | PMID:15064155 PMID:17716812 PMID:18801367 PMID:26022396 PMID:26812056 | Esr1 | increases expression | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | o,p'-DDT results in increased expression of ESR1 mRNA | PMID:11922773 | Esr1 | multiple interactions | ISO | Esr1 (Rattus norvegicus) | 6480464 | CTD | [o,p'-DDT co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Methoxychlor co-treated with Endosulfan co-treated with DDT] results in increased activity of ESR1 protein; o,p'-DDT inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | PMID:28531659 PMID:9860891 | Esr1 | multiple interactions | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [o,p'-DDT results in decreased expression of ESR1 mRNA]; [Estradiol co-treated with Genistein co-treated with o,p'-DDT] affects the expression of ESR1 mRNA; [o,p'-DDT co-treated with Methoxychlor co-treated with Dieldrin] results in increased expression of ESR1 mRNA; Fulvestrant inhibits the reaction [o,p'-DDT results in decreased expression of ESR1 mRNA]; o,p'-DDT binds to and results in increased activity of ESR1 protein; o,p'-DDT inhibits the reaction [Estradiol binds to ESR1 protein]; o,p'-DDT promotes the reaction [Estradiol results in increased activity of ESR1 protein] | PMID:11922773 PMID:12676605 PMID:14579009 PMID:16626760 PMID:20206645 PMID:20362049 PMID:20435135 PMID:25012808 PMID:26812056 PMID:29162470 PMID:33049310 PMID:8930550 PMID:9751507 | | ||||||||||||||||||||||
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