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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3044
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Map2
Name: microtubule-associated protein 2
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Map2affects expressionEXP 6480464CTDbisphenol A affects the expression of MAP2 mRNAPMID:25181051
Map2decreases expressionISOMAP2 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of MAP2 mRNA; bisphenol A results in decreased expression of MAP2 proteinPMID:20678512 PMID:27685785 PMID:34748853 PMID:35069845
Map2decreases expressionISOMap2 (Mus musculus)6480464CTDbisphenol A results in decreased expression of MAP2 mRNA; bisphenol A results in decreased expression of MAP2 proteinPMID:32156529 PMID:32512148
Map2increases methylationISOMAP2 (Homo sapiens)6480464CTDbisphenol A results in increased methylation of MAP2 genePMID:31601247
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