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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1565646
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sox2
Name: SRY-box transcription factor 2
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sox2affects methylationEXP 6480464CTDbisphenol A affects the methylation of SOX2 promoterPMID:27415467
Sox2decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of SOX2 mRNAPMID:25181051 PMID:29097150
Sox2decreases methylationEXP 6480464CTDbisphenol A results in decreased methylation of SOX2 promoterPMID:28728135
Sox2increases expressionEXP 6480464CTDbisphenol A results in increased expression of SOX2 mRNAPMID:27415467 PMID:30387366
Sox2affects methylationISOSox2 (Mus musculus)6480464CTDbisphenol A affects the methylation of SOX2 promoterPMID:27334623
Sox2decreases expressionISOSOX2 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of SOX2 mRNAPMID:16474171 PMID:25051057
Sox2decreases expressionISOSox2 (Mus musculus)6480464CTDbisphenol A results in decreased expression of SOX2 mRNAPMID:35219798
Sox2increases expressionISOSOX2 (Homo sapiens)6480464CTDbisphenol A results in increased expression of SOX2 mRNA; bisphenol A results in increased expression of SOX2 proteinPMID:28244015 PMID:35069845 PMID:37834465
Sox2increases expressionISOSox2 (Mus musculus)6480464CTDbisphenol A results in increased expression of SOX2 mRNA; bisphenol A results in increased expression of SOX2 proteinPMID:23719110 PMID:24090592 PMID:31288075
Sox2multiple interactionsISOSOX2 (Homo sapiens)6480464CTDbisphenol A promotes the reaction [CREB1 protein modified form binds to SOX2 enhancer]PMID:28244015
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