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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1347423
Species: Homo sapiens
RGD Object: Gene
Symbol: HLA-G
Name: major histocompatibility complex, class I, G
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HLA-Gaffects methylationEXP 6480464CTDbisphenol A affects the methylation of HLA-G genePMID:31601247
HLA-Gdecreases expressionEXP 6480464CTDbisphenol A results in decreased expression of HLA-G mRNA; bisphenol A results in decreased expression of HLA-G proteinPMID:33953208
HLA-Gdecreases methylationEXP 6480464CTDbisphenol A results in decreased methylation of HLA-G promoterPMID:33953208
HLA-Gmultiple interactionsEXP 6480464CTD[bisphenol A co-treated with Fulvestrant] results in decreased methylation of HLA-G genePMID:31601247
HLA-Gdecreases expressionISORT1-M3-1 (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of RT1-M3-1 mRNAPMID:34947998
HLA-Gincreases expressionISORT1-M3-1 (Rattus norvegicus)6480464CTDbisphenol A results in increased expression of HLA-G mRNAPMID:25181051
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