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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2325598
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mir21
Name: microRNA 21
Acc ID: CHEBI:33007
Term: chromium(6+)
Definition: A monoatomic hexacation that has formula Cr.
Chemical ID: MESH:C074702
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mir21increases expressionISOMIR21 (Homo sapiens)6480464CTDchromium hexavalent ion results in increased expression of MIR21 mRNAPMID:27323401 PMID:27344173 PMID:28881718
Mir21increases expressionISOMir21a (Mus musculus)6480464CTDchromium hexavalent ion results in increased expression of MIR21 mRNAPMID:27323401
Mir21increases response to substanceISOMIR21 (Homo sapiens)6480464CTDMIR21 mRNA results in increased susceptibility to chromium hexavalent ionPMID:27344173
Mir21multiple interactionsISOMIR21 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [chromium hexavalent ion results in increased expression of MIR21 mRNA]; CAT protein inhibits the reaction [chromium hexavalent ion results in increased expression of MIR21 mRNA]; chromium hexavalent ion promotes the reaction [STAT3 protein binds to MIR21 promoter]; MIR21 mRNA affects the reaction [chromium hexavalent ion results in decreased expression of PDCD4 protein]; Quercetin inhibits the reaction [chromium hexavalent ion results in increased expression of MIR21 mRNA]; STAT3 protein affects the reaction [chromium hexavalent ion results in increased expression of MIR21 mRNA]PMID:27323401 PMID:27344173 PMID:28881718
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