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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732334
Species: Homo sapiens
RGD Object: Gene
Symbol: TYMS
Name: thymidylate synthetase
Acc ID: CHEBI:31348
Term: capecitabine
Definition: A carbamate ester that is cytidine in which the hydrogen at position 5 is replaced by fluorine and in which the amino group attached to position 4 is converted into its N-(penyloxy)carbonyl derivative. Capecitabine is a antineoplastic agent used in the treatment of cancers.
Chemical ID: MESH:C110904
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TYMSaffects expressionEXP 6480464CTDCapecitabine affects the expression of TYMS mRNAPMID:16438929
TYMSdecreases response to substanceEXP 6480464CTDTYMS protein results in decreased susceptibility to CapecitabinePMID:16734730
TYMSmultiple interactionsEXP 6480464CTD[TYMS enhancer polymorphism co-treated with VEGFA gene SNP] affects the susceptibility to [Capecitabine co-treated with oxaliplatin]PMID:21048041
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