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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2702
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Glo1
Name: glyoxalase 1
Acc ID: CHEBI:31162
Term: acemetacin
Definition: A carboxylic ester that is the carboxymethyl ester of indometacin. A non-steroidal anti-inflammatory drug, it is used in the treatment of rheumatoid arthritis, osteoarthritis, and low back pain, as well as for postoperative pain and inflammation. Its activity is due to both acemetacin and its major metabolite, indometacin.
Chemical ID: MESH:C026784
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Glo1decreases activityISOGlo1 (Mus musculus)6480464CTDacemetacin results in decreased activity of GLO1 proteinPMID:17243824
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