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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62109
Species: Mus musculus
RGD Object: Gene
Symbol: Col1a1
Name: collagen, type I, alpha 1
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Col1a1multiple interactionsEXP 6480464CTDArsenic Trioxide inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA]; Arsenic Trioxide inhibits the reaction [Bleomycin results in increased expression of COL1A1 protein]PMID:24762191
Col1a1decreases expressionISOCOL1A1 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of COL1A1 mRNAPMID:30317545
Col1a1increases expressionISOCOL1A1 (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of COL1A1 proteinPMID:19364129
Col1a1multiple interactionsISOCOL1A1 (Homo sapiens)6480464CTDArsenic Trioxide inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; Arsenic Trioxide inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]PMID:24762191 PMID:30317545 PMID:35276128
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