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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1314001
Species: Homo sapiens
RGD Object: Gene
Symbol: PINK1
Name: PTEN induced kinase 1
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PINK1increases expressionEXP 6480464CTDArsenic Trioxide results in increased expression of PINK1 proteinPMID:27318970
PINK1multiple interactionsEXP 6480464CTD3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [Arsenic Trioxide results in increased expression of PINK1 protein]; Cyclosporine inhibits the reaction [Arsenic Trioxide results in increased expression of PINK1 protein]PMID:27318970
PINK1decreases expressionISOPink1 (Rattus norvegicus)6480464CTDArsenic Trioxide results in decreased expression of PINK1 proteinPMID:30551535
PINK1multiple interactionsISOPink1 (Rattus norvegicus)6480464CTDTaurine inhibits the reaction [Arsenic Trioxide results in decreased expression of PINK1 protein]PMID:30551535
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