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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11186
Species: Mus musculus
RGD Object: Gene
Symbol: Pth
Name: parathyroid hormone
Acc ID: CHEBI:30207
Term: phosphorus(.)
Definition: A monoatomic phosphorus that has formula P.
Chemical ID: MESH:D010758
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pthdecreases abundanceISOPth (Rattus norvegicus)6480464CTDPTH protein results in decreased abundance of PhosphorusPMID:17476578
Pthdecreases stabilityISOPth (Rattus norvegicus)6480464CTDPhosphorus deficiency results in decreased stability of PTH mRNAPMID:18583400
Pthmultiple interactionsISOPth (Rattus norvegicus)6480464CTD[Adenine co-treated with Phosphorus] results in increased expression of PTH mRNA; [Adenine co-treated with Phosphorus] results in increased expression of PTH protein; N-(2-chlorophenylpropyl)-1-(3-methoxyphenyl)ethylamine inhibits the reaction [[Adenine co-treated with Phosphorus] results in increased expression of PTH protein]; Phosphorus deficiency inhibits the reaction [HNRNPD protein binds to PTH 3' UTR]; Phosphorus deficiency promotes the reaction [KHSRP protein binds to PTH 3' UTR]PMID:16291838 PMID:18583400
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