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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62396
Species: Mus musculus
RGD Object: Gene
Symbol: Ddit3
Name: DNA-damage inducible transcript 3
Acc ID: CHEBI:29866
Term: arsenite(3-)
Definition: An arsenite ion resulting from the removal of all three protons from the hydroxy groups of arsenous acid.
Chemical ID: MESH:C015001
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ddit3increases expressionEXP 6480464CTDarsenite results in increased expression of DDIT3 mRNA; arsenite results in increased expression of DDIT3 proteinPMID:20589738 PMID:25547999 PMID:29109149 PMID:32443253
Ddit3multiple interactionsEXP 6480464CTD2-(methylamino)isobutyric acid inhibits the reaction [arsenite results in increased expression of DDIT3 mRNA]; CALR protein affects the reaction [arsenite results in increased expression of DDIT3 protein]; EIF2S1 protein modified form affects the reaction [arsenite results in increased expression of DDIT3 protein]; Sirolimus inhibits the reaction [arsenite results in increased expression of DDIT3 protein]; Taurine inhibits the reaction [arsenite results in increased expression of DDIT3 protein]PMID:22215663 PMID:25547999 PMID:29109149 PMID:32443253
Ddit3increases expressionISODdit3 (Rattus norvegicus)6480464CTDarsenite results in increased expression of DDIT3 mRNA; arsenite results in increased expression of DDIT3 proteinPMID:18077580 PMID:18226606 PMID:22425709 PMID:23123503
Ddit3increases expressionISODDIT3 (Homo sapiens)6480464CTDarsenite results in increased expression of DDIT3 mRNA; arsenite results in increased expression of DDIT3 proteinPMID:14604972 PMID:22215663 PMID:22959463 PMID:26677073 PMID:29109149
Ddit3multiple interactionsISODdit3 (Rattus norvegicus)6480464CTDAcetylcysteine inhibits the reaction [arsenite results in increased expression of DDIT3 protein]PMID:18077580
Ddit3multiple interactionsISODDIT3 (Homo sapiens)6480464CTDarsenite promotes the reaction [G3BP1 protein binds to DDIT3 mRNA]; Sirolimus inhibits the reaction [arsenite results in increased expression of DDIT3 mRNA]; Sirolimus inhibits the reaction [arsenite results in increased expression of DDIT3 protein]; SLC38A2 mutant form inhibits the reaction [arsenite results in increased expression of DDIT3 mRNA]; SLC38A2 mutant form inhibits the reaction [arsenite results in increased expression of DDIT3 protein]PMID:22215663 PMID:32406909
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