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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1349180
Species: Homo sapiens
RGD Object: Gene
Symbol: PLXNA3
Name: plexin A3
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PLXNA3increases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of PLXNA3 mRNAPMID:32234424
PLXNA3increases methylationEXP 6480464CTDBenzo(a)pyrene results in increased methylation of PLXNA3 5' UTR; Benzo(a)pyrene results in increased methylation of PLXNA3 promoterPMID:27901495
PLXNA3increases mutagenesisEXP 6480464CTDBenzo(a)pyrene results in increased mutagenesis of PLXNA3 genePMID:25435355
PLXNA3multiple interactionsISOPlxna3 (Mus musculus)6480464CTDBenzo(a)pyrene promotes the reaction [AHR protein binds to PLXNA3 promoter]PMID:19654925
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