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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1310046
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adamts16
Name: ADAM metallopeptidase with thrombospondin type 1 motif, 16
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Adamts16affects methylationISOADAMTS16 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of ADAMTS16 intron; Benzo(a)pyrene affects the methylation of ADAMTS16 promoterPMID:27901495 PMID:30157460
Adamts16decreases expressionISOAdamts16 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of ADAMTS16 mRNAPMID:15894712
Adamts16increases expressionISOADAMTS16 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of ADAMTS16 mRNAPMID:32234424
Adamts16increases methylationISOADAMTS16 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of ADAMTS16 3' UTR; Benzo(a)pyrene results in increased methylation of ADAMTS16 exonPMID:27901495
Adamts16increases mutagenesisISOADAMTS16 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased mutagenesis of ADAMTS16 genePMID:25435355
Adamts16multiple interactionsISOAdamts16 (Mus musculus)6480464CTD[arsenite co-treated with Benzo(a)pyrene] results in decreased expression of ADAMTS16 mRNAPMID:15894712
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