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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1304887
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dscaml1
Name: DS cell adhesion molecule-like 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dscaml1affects methylationISODSCAML1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of DSCAML1 exon; Benzo(a)pyrene affects the methylation of DSCAML1 intron; Benzo(a)pyrene affects the methylation of DSCAML1 promoterPMID:27901495 PMID:30157460
Dscaml1decreases expressionISODSCAML1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of DSCAML1 mRNAPMID:21871943
Dscaml1decreases methylationISODSCAML1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of DSCAML1 3' UTRPMID:27901495
Dscaml1decreases methylationISODscaml1 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased methylation of DSCAML1 intronPMID:27901495
Dscaml1increases methylationISODSCAML1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of DSCAML1 exonPMID:27901495
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