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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345007
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP2E1
Name: cytochrome P450 family 2 subfamily E member 1
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP2E1decreases expressionEXP 6480464CTDsodium arsenite results in decreased expression of CYP2E1 mRNAPMID:29301061
CYP2E1decreases response to substanceEXP 6480464CTDCYP2E1 protein results in decreased susceptibility to sodium arsenitePMID:19154403
CYP2E1decreases expressionISOCyp2e1 (Mus musculus)6480464CTDsodium arsenite results in decreased expression of CYP2E1 mRNAPMID:17350061 PMID:17451858
CYP2E1increases expressionISOCyp2e1 (Mus musculus)6480464CTDsodium arsenite results in increased expression of CYP2E1 mRNA; sodium arsenite results in increased expression of CYP2E1 proteinPMID:25065748 PMID:29044176
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