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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735602
Species: Mus musculus
RGD Object: Gene
Symbol: Bmp2
Name: bone morphogenetic protein 2
Acc ID: CHEBI:28940
Term: calciol
Definition: A hydroxy seco-steroid that is (5Z,7E)-9,10-secocholesta-5,7,10(19)-triene in which the pro-S hydrogen at position 3 has been replaced by a hydroxy group. It is the inactive form of vitamin D3, being hydroxylated in the liver to calcidiol (25-hydroxyvitamin D3), which is then further hydroxylated in the kidney to give calcitriol (1,25-dihydroxyvitamin D3), the active hormone.
Chemical ID: MESH:D002762
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bmp2increases expressionEXP 6480464CTDCholecalciferol results in increased expression of BMP2 mRNAPMID:17170073
Bmp2multiple interactionsEXP 6480464CTDBMP2 protein promotes the reaction [Cholecalciferol results in increased expression of CTNNB1 mRNA]PMID:17170073
Bmp2multiple interactionsISOBMP2 (Homo sapiens)6480464CTD[Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid co-treated with Cholecalciferol] results in increased expression of BMP2 mRNA; PARG mRNA promotes the reaction [[Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid co-treated with Cholecalciferol] results in increased expression of BMP2 mRNA]PMID:22940495
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