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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732442
Species: Mus musculus
RGD Object: Gene
Symbol: Txn1
Name: thioredoxin 1
Acc ID: CHEBI:28939
Term: N-acetyl-L-cysteine
Definition: An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.
Chemical ID: MESH:D000111
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Txn1multiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [arsenic trioxide results in decreased expression of TXN protein]; Acetylcysteine inhibits the reaction [Rotenone inhibits the reaction [TXN protein binds to and results in decreased activity of MAP3K5 protein]]PMID:16449798 PMID:24157283
Txn1decreases expressionISOTXN (Homo sapiens)6480464CTDAcetylcysteine results in decreased expression of TXN proteinPMID:17959236
Txn1multiple interactionsISOTXN (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [Acrolein results in increased oxidation of TXN protein]; Acetylcysteine inhibits the reaction [Mercuric Chloride results in decreased expression of TXN protein]; Acetylcysteine inhibits the reaction [NCX 4040 results in increased oxidation of TXN1 protein]PMID:17959236 PMID:18023956 PMID:18922898
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