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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708428
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akr1c3
Name: aldo-keto reductase family 1, member C3
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akr1c3affects reductionISOAKR1C3 (Homo sapiens)6480464CTDAKR1C3 protein affects the reduction of DoxorubicinPMID:18635746
Akr1c3decreases expressionISOAKR1C3 (Homo sapiens)6480464CTDDoxorubicin results in decreased expression of AKR1C3 mRNAPMID:29803840
Akr1c3increases metabolic processingISOAKR1C3 (Homo sapiens)6480464CTDAKR1C3 results in increased metabolism of DoxorubicinPMID:20837989
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