GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ppara | decreases expression | EXP | | 6480464 | CTD | Doxorubicin results in decreased expression of PPARA mRNA; Doxorubicin results in decreased expression of PPARA protein | PMID:17671096 PMID:28865727 PMID:31570982 | Ppara | multiple interactions | EXP | | 6480464 | CTD | [PPARA protein binds to RELA protein] inhibits the reaction [Doxorubicin results in increased localization of RELA protein]; PPARA protein affects the reaction [PTGS1 protein inhibits the reaction [Doxorubicin results in increased cleavage of CASP3 protein]]; PPARA protein inhibits the reaction [Doxorubicin results in increased abundance of Reactive Oxygen Species]; PPARA protein inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein] | PMID:17671096 | Ppara | decreases expression | ISO | PPARA (Homo sapiens) | 6480464 | CTD | Doxorubicin results in decreased expression of PPARA mRNA | PMID:29803840 | Ppara | increases expression | ISO | Ppara (Mus musculus) | 6480464 | CTD | Doxorubicin results in increased expression of PPARA mRNA | PMID:31768571 | | ||||||||||||||||||||||
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