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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1312043
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cox15
Name: cytochrome c oxidase assembly homolog COX15
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cox15decreases expressionISOCOX15 (Homo sapiens)6480464CTDDoxorubicin results in decreased expression of COX15 mRNAPMID:29803840
Cox15increases expressionISOCox15 (Mus musculus)6480464CTDDoxorubicin results in increased expression of COX15 mRNAPMID:26873546
Cox15multiple interactionsISOCox15 (Mus musculus)6480464CTD[Doxorubicin co-treated with Dexrazoxane] results in decreased expression of COX15 mRNAPMID:26873546
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