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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620360
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfe2l2
Name: NFE2 like bZIP transcription factor 2
Acc ID: CHEBI:28445
Term: vincristine
Definition: A vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer.
Chemical ID: MESH:D014750
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2decreases expressionEXP 6480464CTDVincristine results in decreased expression of NFE2L2 mRNA; Vincristine results in decreased expression of NFE2L2 proteinPMID:33038355 PMID:34939713 PMID:36808657
Nfe2l2multiple interactionsEXP 6480464CTDcoenzyme Q10 inhibits the reaction [Vincristine results in decreased expression of NFE2L2 mRNA]; Quercetin inhibits the reaction [Vincristine results in decreased expression of NFE2L2 protein]PMID:33038355 PMID:34939713 PMID:36808657
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