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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737547
Species: Mus musculus
RGD Object: Gene
Symbol: Cbr1
Name: carbonyl reductase 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cbr1affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of CBR1 mRNAPMID:20702594 PMID:21570461
Cbr1increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of CBR1 mRNAPMID:18796159 PMID:19933214
Cbr1multiple interactionsEXP 6480464CTD[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of CBR1 mRNA; [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CBR1 mRNAPMID:16214954 PMID:17942748
Cbr1affects expressionISOCbr1 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin affects the expression of CBR1 mRNAPMID:22298810
Cbr1decreases expressionISOCbr1 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of CBR1 mRNAPMID:33387578
Cbr1increases expressionISOCbr1 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in increased expression of CBR1 proteinPMID:19492234
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