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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1590928
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdc45
Name: cell division cycle 45
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdc45decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of CDC45 mRNAPMID:32109520
Cdc45increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of CDC45 mRNAPMID:33387578
Cdc45affects expressionISOCDC45 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin affects the expression of CDC45 mRNAPMID:22574217
Cdc45affects expressionISOCdc45 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of CDC45 mRNAPMID:21570461
Cdc45decreases expressionISOCDC45 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in decreased expression of CDC45 mRNAPMID:21632981 PMID:21802500
Cdc45multiple interactionsISOCDC45 (Homo sapiens)6480464CTD[Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CDC45 mRNAPMID:14761676
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