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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10083
Species: Mus musculus
RGD Object: Gene
Symbol: Adcy6
Name: adenylate cyclase 6
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Adcy6affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of ADCY6 mRNAPMID:21570461
Adcy6multiple interactionsEXP 6480464CTD[Tetrachlorodibenzodioxin affects the methylation of ADCY6 intron] which results in increased expression of ADCY6 mRNA; [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADCY6 mRNAPMID:17942748 PMID:33017471
Adcy6decreases expressionISOAdcy6 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of ADCY6 mRNAPMID:18796159 PMID:34747641
Adcy6increases expressionISOADCY6 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of ADCY6 mRNAPMID:29704546
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