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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737547
Species: Mus musculus
RGD Object: Gene
Symbol: Cbr1
Name: carbonyl reductase 1
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cbr1increases expressionEXP 6480464CTDGenistein results in increased expression of CBR1 mRNAPMID:34942354
Cbr1multiple interactionsEXP 6480464CTD[mono-(2-ethylhexyl)phthalate co-treated with Genistein] results in increased expression of CBR1 mRNAPMID:34942354
Cbr1increases expressionISOCBR1 (Homo sapiens)6480464CTDGenistein results in increased expression of CBR1 mRNAPMID:16705744
Cbr1multiple interactionsISOCBR1 (Homo sapiens)6480464CTD[Genistein co-treated with NADP] binds to CBR1 proteinPMID:25526675
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