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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732793
Species: Homo sapiens
RGD Object: Gene
Symbol: PAK2
Name: p21 (RAC1) activated kinase 2
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PAK2multiple interactionsISOPak2 (Mus musculus)6480464CTDPAK2 protein modified form promotes the reaction [Cisplatin results in increased activity of CASP3 protein]; PAK2 protein modified form promotes the reaction [Cisplatin results in increased activity of CASP6 protein]; PAK2 protein modified form promotes the reaction [Cisplatin results in increased activity of CASP7 protein]PMID:21499899
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