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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1359315
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Maf1
Name: MAF1 homolog, negative regulator of RNA polymerase III
Acc ID: CHEBI:27641
Term: cycloheximide
Definition: A dicarboximide that is 4-(2-hydroxyethyl)piperidine-2,6-dione in which one of the hydrogens attached to the carbon bearing the hydroxy group is replaced by a 3,5-dimethyl-2-oxocyclohexyl group. It is an antibiotic produced by the bacterium Streptomyces griseus.
Chemical ID: MESH:D003513
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Maf1increases degradationISOMAF1 (Homo sapiens)6480464CTDCycloheximide results in increased degradation of MAF1 proteinPMID:31645432
Maf1multiple interactionsISOMAF1 (Homo sapiens)6480464CTDBortezomib inhibits the reaction [Cycloheximide results in increased degradation of MAF1 protein]; CUL2 protein affects the reaction [Cycloheximide results in increased degradation of MAF1 protein]; Cycloheximide inhibits the reaction [Sirolimus results in increased expression of MAF1 protein]; PSMD1 protein affects the reaction [Cycloheximide results in increased degradation of MAF1 protein]PMID:31645432
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