GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Col1a1 | decreases expression | EXP | | 6480464 | CTD | Carbon Tetrachloride results in decreased expression of COL1A1 mRNA | PMID:17640975 | Col1a1 | increases expression | EXP | | 6480464 | CTD | Carbon Tetrachloride results in increased expression of COL1A1 mRNA; Carbon Tetrachloride results in increased expression of COL1A1 protein | PMID:11481614 PMID:12540776 PMID:15056808 PMID:16118408 PMID:16539848 PMID:17484886 PMID:17962354 PMID:18263696 PMID:18429990 PMID:20438794 PMID:21151953 PMID:23798564 PMID:24639359 PMID:25566828 PMID:26435214 PMID:26443840 PMID:26644586 PMID:26739621 PMID:26806094 PMID:26921287 PMID:27042213 PMID:27318789 PMID:27339419 PMID:27396813 PMID:27477297 PMID:27601294 PMID:27693115 PMID:27865848 PMID:27939986 PMID:28286204 PMID:28527913 PMID:29250925 PMID:29535048 PMID:29987408 PMID:30538632 PMID:31816328 PMID:31830547 PMID:32659284 PMID:32956689 PMID:33309619 PMID:33640489 PMID:34191077 PMID:34224798 PMID:35101388 PMID:35405287 PMID:36368619 PMID:36555680 PMID:37573684 PMID:37582412 PMID:38042390 | Col1a1 | multiple interactions | EXP | | 6480464 | CTD | (+)-JQ1 compound inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid ethyl amide inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid ethyl amide inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 protein]; 5-(3-(4-(4-benzylpiperazin-1-yl)-N-(4-phenylthiazol-2-yl))propanamide inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 protein]; [Dietary Fats co-treated with Carbon Tetrachloride] results in increased expression of COL1A1 protein; [GJB1 protein affects the susceptibility to Carbon Tetrachloride] which affects the expression of COL1A1 mRNA; alisol B 23-acetate inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; alisol B 23-acetate inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 protein]; alisol B inhibits the reaction [[Dietary Fats co-treated with Carbon Tetrachloride] results in increased expression of COL1A1 protein]; Carbon Tetrachloride deficiency inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; Carbon Tetrachloride deficiency inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 protein]; Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; cucurbitacin B inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; CXCL1 protein promotes the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; epigallocatechin gallate inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; ESRRG protein affects the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; F2R protein affects the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; fuzheng huayu inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; GANT 61 inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; GSK5182 inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; HAS3 protein affects the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; hemistepsin inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; HIF1A protein affects the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; HTS 466284 promotes the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; IL10 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; Ivermectin inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; Ivermectin inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 protein]; LEP protein promotes the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; MGAT5 protein affects the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; MICAL2 mRNA promotes the reaction [Carbon Tetrachloride results in increased expression of COL1A1 protein]; MIR203 mRNA inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 protein]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 protein]]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of COL1A1 protein]; NPLC 0393 inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; PANX1 protein affects the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; PPIC protein affects the reaction [Carbon Tetrachloride results in increased expression of COL1A1 protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 protein]]; puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; Quercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; RDH13 protein promotes the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; SHC1 protein promotes the reaction [Carbon Tetrachloride results in increased expression of COL1A1 protein]; Silymarin inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; Sirolimus inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 protein]; STF 083010 inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; Tetrachlorodibenzodioxin promotes the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 protein]; tianhuang inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; TUG1 protein affects the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; Vildagliptin inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; Vitamin D inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; VWF gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA] | PMID:11481614 PMID:16118408 PMID:16539848 PMID:17962354 PMID:20438794 PMID:21151953 PMID:23798564 PMID:24639359 PMID:25566828 PMID:26443840 PMID:26644586 PMID:27042213 PMID:27268753 PMID:27318789 PMID:27396813 PMID:27477297 PMID:27601294 PMID:27693115 PMID:27865848 PMID:28527913 PMID:29250925 PMID:29987408 PMID:30538632 PMID:31816328 PMID:31830547 PMID:32659284 PMID:32956689 PMID:33309619 PMID:33640489 PMID:34191077 PMID:34224798 PMID:35101388 PMID:35405287 PMID:35745142 PMID:36555680 PMID:37573684 PMID:37582412 PMID:38042390 | Col1a1 | affects expression | ISO | Col1a1 (Rattus norvegicus) | 6480464 | CTD | Carbon Tetrachloride affects the expression of COL1A1 mRNA | PMID:23262250 | Col1a1 | decreases expression | ISO | COL1A1 (Homo sapiens) | 6480464 | CTD | Carbon Tetrachloride results in decreased expression of COL1A1 mRNA | PMID:18207697 | Col1a1 | increases expression | ISO | Col1a1 (Rattus norvegicus) | 6480464 | CTD | Carbon Tetrachloride results in increased expression of COL1A1 mRNA; Carbon Tetrachloride results in increased expression of COL1A1 protein | PMID:12632512 PMID:15860571 PMID:16239168 PMID:16420518 PMID:16780995 PMID:17157831 PMID:17166617 PMID:17485851 PMID:17708605 PMID:18006644 PMID:18054572 PMID:22841775 PMID:23146752 PMID:23958495 PMID:24211420 PMID:27350269 PMID:27818223 PMID:30010033 | Col1a1 | increases expression | ISO | COL1A1 (Homo sapiens) | 6480464 | CTD | Carbon Tetrachloride results in increased expression of COL1A1 mRNA; Carbon Tetrachloride results in increased expression of COL1A1 protein | PMID:17030193 | Col1a1 | multiple interactions | ISO | Col1a1 (Rattus norvegicus) | 6480464 | CTD | [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of COL1A1 mRNA; [Carbon Tetrachloride co-treated with Interleukin 1 Receptor Antagonist Protein] results in increased expression of COL1A1 mRNA; Celecoxib promotes the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; Cystamine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; Dalteparin inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; Drugs, Chinese Herbal inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; KNG1 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 protein]; methyl ferulate inhibits the reaction [[Carbon Tetrachloride co-treated with Ethanol] results in increased expression of COL1A1 mRNA]; Plant Extracts inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; Resveratrol inhibits the reaction [Carbon Tetrachloride affects the expression of COL1A1 mRNA]; Sulfasalazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 protein] | PMID:12632512 PMID:15633128 PMID:16420518 PMID:16762003 PMID:17157831 PMID:17166617 PMID:17708605 PMID:18006644 PMID:18054572 PMID:23146752 PMID:23262250 PMID:27818223 PMID:30543783 | Col1a1 | multiple interactions | ISO | COL1A1 (Homo sapiens) | 6480464 | CTD | Pentoxifylline promotes the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA] | PMID:18207697 | | ||||||||||||||||||||||
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