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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3734
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sord
Name: sorbitol dehydrogenase
Acc ID: CHEBI:27385
Term: tetrachloromethane
Definition: A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Chemical ID: MESH:D002251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sorddecreases expressionEXP 6480464CTDCarbon Tetrachloride results in decreased expression of SORD mRNAPMID:31150632
Sordincreases expressionEXP 6480464CTDCarbon Tetrachloride results in increased expression of SORD proteinPMID:17374462
Sordincreases secretionEXP 6480464CTDCarbon Tetrachloride results in increased secretion of SORD proteinPMID:10757424
Sordmultiple interactionsEXP 6480464CTDcynandione A inhibits the reaction [Carbon Tetrachloride results in increased secretion of SORD protein]; schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of SORD mRNA]PMID:10757424 PMID:31150632
Sorddecreases expressionISOSord (Mus musculus)6480464CTDCarbon Tetrachloride results in decreased expression of SORD mRNAPMID:31919559
Sordincreases activityISOSord (Mus musculus)6480464CTDCarbon Tetrachloride results in increased activity of SORD proteinPMID:17177172
Sordmultiple interactionsISOSord (Mus musculus)6480464CTDDimethyl Sulfoxide inhibits the reaction [Carbon Tetrachloride results in increased activity of SORD protein]PMID:17177172
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