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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3185
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nos2
Name: nitric oxide synthase 2
Acc ID: CHEBI:27385
Term: tetrachloromethane
Definition: A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Chemical ID: MESH:D002251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nos2decreases expressionEXP 6480464CTDCarbon Tetrachloride results in decreased expression of NOS2 mRNAPMID:19784758
Nos2increases expressionEXP 6480464CTDCarbon Tetrachloride results in increased expression of NOS2; Carbon Tetrachloride results in increased expression of NOS2 mRNA; Carbon Tetrachloride results in increased expression of NOS2 proteinPMID:12741479 PMID:15135310 PMID:15745444 PMID:16325526 PMID:16614485 PMID:16964402 PMID:17009398 PMID:17595544 PMID:22705329 PMID:23146695 PMID:23146752 PMID:24975872 PMID:26929000 PMID:29233029
Nos2multiple interactionsEXP 6480464CTDCarbon Tetrachloride results in increased expression of and results in increased activity of NOS2 protein; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 mRNA]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 mRNA]; IGF1 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; IL11 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 mRNA]; Plant Extracts inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 mRNA]; puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; Quercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; S-allylcysteine inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2]; Telmisartan inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; Thioctic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 mRNA]; tin mesoporphyrin inhibits the reaction [IL11 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 mRNA]]PMID:12741479 PMID:12943827 PMID:15745444 PMID:16614485 PMID:16964402 PMID:22705329 PMID:23146695 PMID:23146752 PMID:24975872 PMID:26929000 PMID:29233029
Nos2decreases response to substanceISONos2 (Mus musculus)6480464CTDNOS2 gene mutant form results in decreased susceptibility to Carbon TetrachloridePMID:17105591
Nos2increases activityISONos2 (Mus musculus)6480464CTDCarbon Tetrachloride results in increased activity of NOS2 proteinPMID:24975834
Nos2increases expressionISONos2 (Mus musculus)6480464CTDCarbon Tetrachloride results in increased expression of NOS2 mRNA; Carbon Tetrachloride results in increased expression of NOS2 proteinPMID:16874658 PMID:17917259 PMID:18187930 PMID:18429990 PMID:19793341 PMID:20438794 PMID:21095217 PMID:21291945 PMID:22902988 PMID:23279844 PMID:23994094 PMID:24530446 PMID:24639359 PMID:25432964 PMID:25445725 PMID:26218279 PMID:29033935 PMID:29964319
Nos2multiple interactionsISONos2 (Mus musculus)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; AM 281 inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 mRNA]; AM 281 inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; baicalin inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 mRNA]; baicalin inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; Berberine inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; bifendate inhibits the reaction [Carbon Tetrachloride results in increased activity of NOS2 protein]; CNR1 protein affects the reaction [Carbon Tetrachloride results in increased expression of NOS2 mRNA]; CNR1 protein affects the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]]; epigallocatechin gallate inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 mRNA]; epigallocatechin gallate inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; ferulic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 mRNA]; ferulic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; Flavonoids inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; Glycyrrhizic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 mRNA]; Glycyrrhizic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; HIF1A protein affects the reaction [Carbon Tetrachloride results in increased expression of NOS2 mRNA]; Lipids inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; neohesperidin dihydrochalcone inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; NOS2 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]; Plant Extracts inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; pyrazolanthrone inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; Quercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; rossicaside B inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; S-methylisothiopseudouronium analog inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 mRNA]; S-methylisothiopseudouronium analog inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; Saponins inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; SB 203580 inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; SC 560 promotes the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]PMID:16874658 PMID:17105591 PMID:17917259 PMID:18187930 PMID:19793341 PMID:20438794 PMID:21095217 PMID:21291945 PMID:22902988 PMID:23279844 PMID:23994094 PMID:24530446 PMID:24639359 PMID:24975834 PMID:25432964 PMID:25445725 PMID:26218279 PMID:29033935 PMID:29964319
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