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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2587
Species: Rattus norvegicus
RGD Object: Gene
Symbol: F3
Name: coagulation factor III, tissue factor
Acc ID: CHEBI:2679
Term: amphetamine
Definition: A racemate comprising equimolar amounts of (R)-amphetamine (also known as levamphetamine or levoamphetamine) and (S)-amphetamine (also known as dexamfetamine or dextroamphetamine.
Chemical ID: MESH:D000661
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
F3increases expressionEXP 6480464CTDAmphetamine results in increased expression of F3 mRNAPMID:30779732
F3increases activityISOF3 (Homo sapiens)6480464CTDAmphetamine results in increased activity of F3 proteinPMID:20118172
F3increases expressionISOF3 (Homo sapiens)6480464CTDAmphetamine results in increased expression of F3 proteinPMID:20118172
F3multiple interactionsISOF3 (Homo sapiens)6480464CTD3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo(2,3-b)pyridine inhibits the reaction [Amphetamine promotes the reaction [TNF protein results in increased expression of F3 protein]]; Amphetamine promotes the reaction [F2 protein results in increased expression of F3 protein]; Amphetamine promotes the reaction [TNF protein results in increased activity of F3 protein]; Amphetamine promotes the reaction [TNF protein results in increased expression of F3 mRNA]; Amphetamine promotes the reaction [TNF protein results in increased expression of F3 protein]; L 750667 inhibits the reaction [Amphetamine promotes the reaction [TNF protein results in increased expression of F3 protein]]PMID:20118172
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