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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2755
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gstm1
Name: glutathione S-transferase mu 1
Acc ID: CHEBI:2504
Term: aflatoxin B1
Definition: An aflatoxin having a tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11.
Chemical ID: MESH:D016604
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gstm1increases expressionEXP 6480464CTDAflatoxin B1 results in increased expression of GSTM1 mRNAPMID:23630614 PMID:25378103 PMID:33354967
Gstm1decreases expressionISOGstm1 (Mus musculus)6480464CTDAflatoxin B1 results in decreased expression of GSTM1 mRNAPMID:19770486
Gstm1increases response to substanceISOGSTM1 (Homo sapiens)6480464CTDGSTM1 gene mutant form results in increased susceptibility to Aflatoxin B1PMID:7892276
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