GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nfe2l2 | affects expression | EXP | | 6480464 | CTD | indole-3-carbinol affects the expression of NFE2L2 mRNA | PMID:21396975 | Nfe2l2 | multiple interactions | EXP | | 6480464 | CTD | [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of NFE2L2 mRNA; Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of NFE2L2 mRNA]; indole-3-carbinol inhibits the reaction [Letrozole results in decreased expression of NFE2L2 protein]; indole-3-carbinol promotes the reaction [Linagliptin inhibits the reaction [Letrozole results in decreased expression of NFE2L2 protein]]; Linagliptin promotes the reaction [indole-3-carbinol inhibits the reaction [Letrozole results in decreased expression of NFE2L2 protein]] | PMID:22129741 PMID:28619389 | Nfe2l2 | affects activity | ISO | Nfe2l2 (Mus musculus) | 6480464 | CTD | indole-3-carbinol affects the activity of NFE2L2 protein | PMID:11309284 | Nfe2l2 | decreases activity | ISO | NFE2L2 (Homo sapiens) | 6480464 | CTD | indole-3-carbinol results in decreased activity of NFE2L2 protein | PMID:16082211 | Nfe2l2 | multiple interactions | ISO | NFE2L2 (Homo sapiens) | 6480464 | CTD | [indole-3-carbinol co-treated with phenethyl isothiocyanate] results in increased expression of NFE2L2 mRNA | PMID:32070777 | Nfe2l2 | multiple interactions | ISO | Nfe2l2 (Mus musculus) | 6480464 | CTD | indole-3-carbinol inhibits the reaction [Doxorubicin affects the expression of and affects the localization of NFE2L2 protein] | PMID:29775573 | |
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