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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1313300
Species: Mus musculus
RGD Object: Gene
Symbol: Mdm2
Name: transformed mouse 3T3 cell double minute 2
Acc ID: CHEBI:229764
Term: selinexor
Definition: A member of the class of triazoles that is 1H-1,2,4-triazole substituted by (1Z)-3-oxo-3-[2-(pyrazin-2-yl)hydrazinyl]prop-1-en-1-yl and 3,5-bis(trifluoromethyl)phenyl groups at positions 1 and 3, respectively. It is a prescription medicine approved for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma.
Chemical ID: MESH:C585161
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mdm2increases expressionISOMDM2 (Homo sapiens)6480464CTDselinexor results in increased expression of MDM2 proteinPMID:37899423
Mdm2multiple interactionsISOMDM2 (Homo sapiens)6480464CTD[INCB057643 co-treated with selinexor] results in increased expression of MDM2 proteinPMID:37899423
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