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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3729
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Snca
Name: synuclein alpha
Acc ID: CHEBI:20067
Term: 3-hydroxybutyric acid
Definition: A straight-chain 3-hydroxy monocarboxylic acid comprising a butyric acid core with a single hydroxy substituent in the 3- position; a ketone body whose levels are raised during ketosis, used as an energy source by the brain during fasting in humans. Also used to synthesise biodegradable plastics.
Chemical ID: MESH:D020155
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sncamultiple interactionsISOSNCA (Homo sapiens)6480464CTD3-Hydroxybutyric Acid inhibits the reaction [SNCA protein results in increased susceptibility to Rotenone]; 3-Hydroxybutyric Acid promotes the reaction [ursodoxicoltaurine inhibits the reaction [SNCA protein results in increased susceptibility to Rotenone]]PMID:16239214
Sncamultiple interactionsISOSnca (Mus musculus)6480464CTD3-Hydroxybutyric Acid affects the reaction [ZFP36 protein affects the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SNCA protein]]; 3-Hydroxybutyric Acid inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SNCA protein]; 3-Hydroxybutyric Acid inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SNCA protein]PMID:36435477
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