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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68424
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dlg4
Name: discs large MAGUK scaffold protein 4
Acc ID: CHEBI:17688
Term: (S)-nicotine
Definition: A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dlg4decreases expressionEXP 6480464CTDNicotine results in decreased expression of DLG4 mRNAPMID:28555334
Dlg4decreases methylationEXP 6480464CTDNicotine results in decreased methylation of DLG4 genePMID:32994467
Dlg4decreases expressionISODlg4 (Mus musculus)6480464CTDNicotine results in decreased expression of DLG4 mRNAPMID:21955143
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