GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nos2 | increases expression | EXP | | 6480464 | CTD | Formaldehyde results in increased expression of NOS2 mRNA; Formaldehyde results in increased expression of NOS2 protein | PMID:12679049 PMID:21983654 PMID:23359814 PMID:23871789 | Nos2 | multiple interactions | EXP | | 6480464 | CTD | [Ascorbic Acid co-treated with Formaldehyde] results in decreased expression of NOS2 mRNA; [Formaldehyde co-treated with Ovalbumin] results in increased expression of NOS2 mRNA; [Formaldehyde results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide; acetovanillone inhibits the reaction [Formaldehyde results in increased expression of NOS2 mRNA]; Indomethacin inhibits the reaction [Formaldehyde results in increased expression of NOS2 mRNA]; Nitric Oxide deficiency inhibits the reaction [Formaldehyde results in increased expression of NOS2 mRNA] | PMID:21983654 PMID:23359814 PMID:23871789 PMID:27020608 | Nos2 | increases expression | ISO | Nos2 (Mus musculus) | 6480464 | CTD | Formaldehyde results in increased expression of NOS2 protein | PMID:30395894 | Nos2 | multiple interactions | ISO | Nos2 (Mus musculus) | 6480464 | CTD | 2-amino-3-(4'-N,N-bis(2-chloroethyl)amino)phenylpropionic acid N-oxide inhibits the reaction [[Formaldehyde co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of NOS2 protein]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Formaldehyde promotes the reaction [ovalbumin-alum results in increased expression of NOS2 mRNA]]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Formaldehyde promotes the reaction [ovalbumin-alum results in increased expression of NOS2 protein]]; [Formaldehyde co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of NOS2 protein; [Thiamethoxam metabolite results in decreased activity of NOS2 protein] which results in increased chemical synthesis of Formaldehyde; epigallocatechin gallate inhibits the reaction [Formaldehyde results in increased expression of NOS2 protein]; Formaldehyde promotes the reaction [ovalbumin-alum results in increased expression of NOS2 mRNA]; Formaldehyde promotes the reaction [ovalbumin-alum results in increased expression of NOS2 protein] | PMID:29197058 PMID:30395894 PMID:37105513 | | ||||||||||||||||||||||
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