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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69287
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sqstm1
Name: sequestosome 1
Acc ID: CHEBI:16796
Term: melatonin
Definition: A member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen atom is replaced by a 2-(5-methoxy-1H-indol-3-yl)ethyl group. It is a hormone secreted by the pineal gland in humans.
Chemical ID: MESH:D008550
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sqstm1multiple interactionsEXP 6480464CTDMelatonin inhibits the reaction [Carbon Tetrachloride results in increased expression of SQSTM1 protein]PMID:26882442
Sqstm1increases expressionISOSqstm1 (Mus musculus)6480464CTDMelatonin results in increased expression of SQSTM1 proteinPMID:37028639
Sqstm1multiple interactionsISOSQSTM1 (Homo sapiens)6480464CTDMelatonin inhibits the reaction [cyfluthrin results in increased expression of SQSTM1 mRNA]PMID:31330490
Sqstm1multiple interactionsISOSqstm1 (Mus musculus)6480464CTDMelatonin inhibits the reaction [Atrazine results in increased expression of SQSTM1 protein]; Melatonin inhibits the reaction [nickel chloride results in decreased expression of SQSTM1 mRNA]; Melatonin inhibits the reaction [nickel chloride results in decreased expression of SQSTM1 protein]; Melatonin inhibits the reaction [Radon results in increased expression of SQSTM1 protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in decreased expression of SQSTM1 mRNA]]PMID:25259610 PMID:33107683 PMID:36421005
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