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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309381
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dicer1
Name: dicer 1 ribonuclease III
Acc ID: CHEBI:167693
Term: GSK343
Definition: A member of the class of indazoles that is 1-isopropyl-1H-indazole-4-carboxamide in which the nitrogen of the carboxamide group is substituted by a (6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl group and in which the indazole ring is substituted at position 6 by a 2-(4-methylpiperazin-1-yl)pyridin-4-yl group. A highly potent and selective EZH2 inhibitor (IC50 = 4 nM).
Chemical ID: MESH:C586265
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dicer1increases expressionISODICER1 (Homo sapiens)6480464CTDGSK343 results in increased expression of DICER1 mRNAPMID:25351418
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