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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736485
Species: Mus musculus
RGD Object: Gene
Symbol: Sqstm1
Name: sequestosome 1
Acc ID: CHEBI:16551
Term: alpha,alpha-trehalose
Definition: A trehalose in which both glucose residues have alpha-configuration at the anomeric carbon.
Chemical ID: MESH:D014199
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sqstm1decreases expressionEXP 6480464CTDTrehalose results in decreased expression of SQSTM1 proteinPMID:29486218
Sqstm1increases expressionEXP 6480464CTDTrehalose results in increased expression of SQSTM1 mRNAPMID:23851366 PMID:30335591
Sqstm1multiple interactionsEXP 6480464CTDTFEB affects the reaction [Trehalose results in increased expression of SQSTM1 mRNA]; Trehalose inhibits the reaction [Dronabinol results in increased expression of SQSTM1 protein]PMID:30335591 PMID:32773031
Sqstm1multiple interactionsISOSQSTM1 (Homo sapiens)6480464CTDTrehalose inhibits the reaction [ovatodiolide results in increased expression of SQSTM1 protein]PMID:38000454
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